Thursday, January 31, 2013

Researchers in U.S. may have received millions in duplicate funding, analysis suggests

Jan. 30, 2013 ? Big Data computation at the Virginia Bioinformatics Institute at Virginia Tech reveals that over the past two decades funding agencies may have awarded millions and possibly billions of dollars to scientists who submitted the same grant request multiple times -- and accepted duplicate funding.

An analysis led by Harold R. Garner, a professor at Virginia Tech, indicates not only that millions in funding may have been granted and used inappropriately, but also that there are techniques to uncover existing instances of duplicate funding and ways to prevent it in the future. The analysis was presented in the comment section of this week's Nature.

Submitting applications with identical or highly similar specific aims, goals, objectives, and hypotheses is allowed; however, accepting duplicate funding for the same project is not.

To estimate the extent of double-funding, Garner and his team, including programmer Lauren McIver, systematically compared 858,717 funded grant and contract summaries using text-similarity (text mining) software followed up by manual review. These summaries were downloaded from public websites in the U.S. for the National Institutes of Health, the National Science Foundation, the Department of Energy, the Department of Defense, and Susan G. Komen for the Cure.

Although the researchers could not definitively determine whether the similar grants were true duplicates -- this would require access to the full grant files, which were not publicly available -- they found strong evidence that tens of millions of dollars may have been spent on grants where at least a portion was already being funded. In the most recent five years (2007-2011), they identified 39 similar grant pairs involving more than $20 million.

"It is quite possible that our detection software missed many cases of duplication," Garner said. "If text similarity software misses as many cases of funding duplications as it does plagiarism of scientific papers we've studied, then the extent of duplication could be much larger. It could be as much as 2.5 percent of total research funding, equivalent to $5.1 billion since 1985."

Co-researcher and medical science ethicist Michael B. Waitzkin said, "In line with the Government Accountability Office report issued February 2012, these findings suggest the research community should undertake a more thorough investigation of the true extent of duplication and establish, clearer and more consistent guidance and coordination of grant and contract funding across agencies, both public and private."

The study did not reveal specific principal investigators or research organizations identified as double-dippers, but said that no instances of double dipping were found at Virginia Tech.

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The above story is reprinted from materials provided by Virginia Tech (Virginia Polytechnic Institute and State University), via Newswise.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Harold R. Garner, Lauren J. McIver, Michael B. Waitzkin. Research Funding: Same work, twice the money? Nature, 2013; 493 (7434): 599 DOI: 10.1038/493599a

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/93MRu-NvVm0/130130132256.htm

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'Eyes free' Siri coming to 2013 Hondas and Acuras

13 hrs.

Honda has announced that the new "eyes?free" mode for Apple's Siri voice assistant will be built into upcoming Honda and Acura vehicles. Honda's not the first to make such a commitment, but it might be the one?putting it into the most cars.

The news came via a press release on Honda's site, in which the company?says that the 2013 Accord will come with eyes-free activation button?as a dealer-installed option. The 2013?Acura RDX and ILX will also get it.

Eyes-free mode isn't a serious change from ordinary Siri operation, except that instead of fumbling around for the home button on your iPhone to launch Siri, you simply hit a button on your steering wheel.

Other manufacturers have also said they'll integrate?eyes-free mode, including Hyundai and GM, although neither has publicly committed to bringing it to a model as popular as the Accord.

Devin Coldewey is a contributing writer for NBC News Digital. His personal website is coldewey.cc.

Source: http://www.nbcnews.com/technology/gadgetbox/eyes-free-siri-coming-2013-hondas-acuras-1B8186530

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Apple iPad Dominates Tablets Market; But Loses Market Share


Research firm IDC has published a brand new report which talks about the worldwide tablet shipments for the fourth quarter of 2012. The report throws some interesting light on the current state of the fast moving tablets segment. According to IDC, the iPad continues to dominate the tablets segment with shipments recording a growth of 48.1 percent year-over year to 22.9 million units. Apple might be?concerned?however at the growth of the tablet?shipments?from Samsung which grew by a astonishing 263 percent to reach 7.9 million units over the same period. Of course,?Samsung?s shipments also included its Windows based tablets.

apple-ipad4-lightning


The overall shipments showed a healthy increase of 75.3 percent year-to-year increase, to hit 51.5 million overall tablets ? up from 29.9 million units during the same time last year. IDC notes that the increase in shipments were due to lower average selling prices for new devices and increased consumer spending during the holidays.

It is pertinent to note that Apple had also recently divulged in their earnings report which states sales of 22.9 million iPad over that last quarter of 2012.
?New product launches from the category?s top vendors, as well as new entrant Microsoft, led to a surge in consumer interest and very robust shipments totals during the holiday season,? said IDC Research Director of Tablets, Tom Mainelli. ?The record-breaking quarter stands in stark contrast to the PC market, which saw shipments decline during the quarter for the first time in more than five years.?

Another thing for concern for Apple is the fact that Apple?s tablets marketshare dropped for the second consecutive quarter and stood at 43.6 percent. Unsurprisingly, Samsung came in second with 15.1 percent. Amazon?s Kindle is doing pretty well as well and holds 11.5 percent of the market.

Apple iPad Dominates Tablets Market; But Loses Market Share

Source: http://feedproxy.google.com/~r/ogfeed/~3/tdPKsXtaxLU/

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Mindy McCready: I Didn't Kill David Wilson!

Source: http://www.thehollywoodgossip.com/2013/01/mindy-mccready-i-didnt-kill-david-wilson/

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Wednesday, January 30, 2013

Kudos to Senators Cornyn, Cruz, and Inhofe (Powerlineblog)

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Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/281490266?client_source=feed&format=rss

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Egypt cruise ship runs aground, all aboard safe

CAIRO (AP) ? Egyptian police officials say a cruise ship has run aground on the Nile River near the southern city of Aswan, but all 120 people aboard survived.

The officials said the ship was travelling to the city of Luxor, north of Aswan, when it hit rocks and took in water before running aground on Tuesday.

Local villagers and police helped rescue all 120 Egyptian passengers and crew.

None of the passengers were injured, said the officials, who spoke on condition of anonymity because they were not authorized to brief the media.

Source: http://news.yahoo.com/egypt-cruise-ship-runs-aground-aboard-safe-183430387.html

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Girls saves mom suffering diabetic attack

A fast thinking 9-year-old Illinois girl was able to help guide her mother to safety after the woman suffered a diabetic attack while driving at speeds of up to 70 mph.

Jennifer Sheridan, 42, was driving her daughter Aleksandra to McDonald's in Frankfort, Ill., after the two had attended a high school basketball game on the evening of Jan. 18. Sheridan, who has type 2 diabetes, had a diabetic attack when her blood sugar suddenly dropped. She told ABCNews.com that she was not aware of what was happening.

"I was still conscious, and talking, my daughter said. I don't remember any of that," Sheridan said. "We went through, she says, a red light, and then I know I kept saying, 'We have to stop.' That was in my mind, but it wasn't clicking."

Sheridan said that they passed her house and the McDonald's. Aleksandra was screaming and crying during the wayward drive, which she says must have lasted 15 to 20 minutes, but kept talking to her mother.

"She says she kept telling me different things, that I was going too fast, or too slow," Sheridan said.

While the car was still moving, Sheridan's husband called. She said that Aleksandra was on phone screaming that they were going off the road.

Her car eventually veered to the right, through a small ditch and a group of trees. At that point Aleksandra turned the car off, preventing the still moving car from hitting a tree.

Luckily, both mother and daughter were unharmed. Once the car was off, Aleksandra slowly fed her mother a chocolate bar that was in the car's cup holder.

"Once we were stopped and she could focus, she fed me," Sheridan said. "She said, 'I kept just giving little pieces so you wouldn't choke.'"

Police and the fire department were called to the scene by a passerby who saw the incident. The story also caught local media attention from WBBM-TV and Fox News.

Sheridan says the next thing she actually remembers was being in the ambulance. Police who arrived on the scene congratulated Aleksandra, and even gave her a yellow duck toy, which they call the "Golden Duck Award for Heroes."

This is not the first time Aleksandra has come to her mom's aid when she had a diabetic attack. Two years ago, while they were in their home, the girl called 911 when she found her mother on the kitchen floor.

Sheridan said that she is now using an insulin pump, which is designed to eliminate lows in blood sugar in diabetics. She said that she will soon be on the list for a new pancreas. With a daughter and a 16-year-old son with cerebral palsy, she says she needs to be in top form. For now, she's happy that both she and Aleksandra are unscathed.

"Every day, I wake up and think, 'Yes!'" she said.

Also Read

Source: http://gma.yahoo.com/blogs/abc-blogs/girl-9-saves-mom-diabetic-attack-while-driving-155739348--abc-news-topstories.html

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Tuesday, January 29, 2013

Google Pledges Pi Million Dollars In Pwnium 3 Prizes

For exploits like that, the black market still pays somewhat better than Google is.

Yes, but if you get caught, you can lose anything you got paid (as the profits of crime) plus go to jail.

Whereas if you sell to Google, you get money, publicity that you can use openly outside of the black market world, and you don't have to worry about going to jail for it.

Also, some people have moral codes which would discourage selling exploits on the black market, but not seeking rewards through something like Pwnium.

Source: http://rss.slashdot.org/~r/Slashdot/slashdotScience/~3/TSkprPKYbgk/story01.htm

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Q&A: Fixing Flash Player Settings - NYTimes.com

Q.

Games won?t work when I use Facebook with Firefox. Is there a problem with that browser?

A.

If Facebook games will not work in Firefox, make sure you have the most recent version of the browser, as well as the most recent version of the Adobe Flash Player plug-in that handles animation and interactivity for some sites. You can see the version of the Flash player installed on the computer by clicking the Adobe Flash Player Help/Find Version page here.

The page has instructions for updating the software if you need to, but if your system is already up to date, you may just need to change the Flash player settings so it saves game information on your computer. To do that, right-click (or hold down the Control key and click) the animated Flash movie at the top of the Find Version page and choose Global Settings from the menu.

In the Flash Player settings box that opens, click the Storage tab. By default, the Flash player is probably set to ?Ask me before allowing new sites to save information on this computer.? (You do have to option to allow any site to save information to the computer, or block any site for storing information as well.) Click the ?Local Storage Settings by Site? button.

In the list of sites that appears, select www.facebook.com and use the pop-up menu under Storage Access to change the setting from Block to either Ask Me or Allow. Close the Flash Player settings box, restart Firefox and try the Facebook game again.

Source: http://gadgetwise.blogs.nytimes.com/2013/01/28/qa-fixing-flash-player-settings/

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Monday, January 28, 2013

The Sunday Shows (TIME)

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Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/279889284?client_source=feed&format=rss

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Green Deal loans scheme to launch

Householders are to be offered long-term loans to help make their homes more energy efficient and cut bills under a new government scheme.

Ministers say the Green Deal, which launches on Monday, will help thousands "stay warm for less".

Under the scheme, households can use cheap loans to spend on energy-saving improvements, such as insulation and new boilers, with no upfront cost.

Campaigners said the project would "not stop fuel poverty rocketing".

The Department of Energy and Climate Change (DECC), which launched the flagship scheme, said it believed hundreds more households than expected had already signed up for assessments to join the project. It said official figures were being collated.

Earlier reports had indicated just five assessments had been carried out ahead of the launch.

Deputy Prime Minister Nick Clegg said: "The Green Deal will help thousands of homes stay warm for less. Those people will benefit from energy saving improvements - and their energy bills will fall.

"The UK green sector is a success story. It is the sixth largest in the world and has a crucial part to play in building a strong economy."

'Cosier' homes

He added: "The Green Deal will support thousands of jobs, not just over the next few years, but in the long-term."

Continue reading the main story

?Start Quote

We call on the prime minister to use money from the carbon tax to super-insulate this country's homes?

End Quote Ed Matthews Energy Bill Revolution

Energy and Climate Change Secretary Edward Davey also praised the "great deal", saying: "Improve the look and feel of your home, make it cosier and at the same time save energy - what's not to like?"

The move to insulate the UK's aged housing stock is designed to save carbon emissions, keep people warm, and make energy affordable, the government said.

Anyone joining the scheme would first have their home reviewed by an independent assessor, advising on possible upgrades, costs and energy saving timescales.

Green Deal providers would then calculate quotes for the proposed work - with households free to get multiple quotes - before carrying out the changes.

Under the deal, improvements are installed at no initial cost. Instead, charges are covered with cheap loans via the not-for-profit Green Deal Finance Company, and recouped gradually over up to 25 years through customers' electricity bills.

But campaigners have warned the scheme does not go far enough.

Ed Matthews, head of fuel poverty campaign group Energy Bill Revolution, said: "The Green Deal and Energy Company Obligation will not stop fuel poverty rocketing in the face of high gas prices."

"We call on the prime minister to use money from the carbon tax to super-insulate this country's homes.

"This will provide households with five times more subsidy to insulate their homes and not add a penny more to energy bills."

"It is enough to eliminate fuel poverty and in time cut bills for everyone. It is the just and fair solution."

Source: http://www.bbc.co.uk/news/uk-21226042#sa-ns_mchannel=rss&ns_source=PublicRSS20-sa

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Weatherman caught playing online game on TV - Pocket-lint

Weatherman caught playing online game on TV. Gaming, Online, China 0

28 January 2013 12:33 GMT / By Rik Henderson

If there's a film crew visiting your office you really should be careful what you're seen doing. Especially if you are in the background of an interview with your boss. And even more so if you work for the Chinese government.

During a news broadcast about the smog-filled skies over Shanghai, Shanghai TV News interviewed a senior meteorologist about the impact of the adverse weather while an assistant could clearly be seen in the background playing Three Kingdoms Killers (Sanguosha), China's favourite online card game, rather than actually doing his job.

Around 25 seconds into the news clip, the leather jacketed employee seems to be completely oblivious to the fact that State news is filming him "goofing off". To make matters worse, it's become quite a viral over the last few days.

Gossip blog Shanghaiist reports that "netizens" have been registering reactions across social networks since its original broadcast on 25 January.

One posted, "Isn't it normal to go to work in order to play Sanguosha?" Another, "I've heard that the Sanguosha game is the favourite computer game of government employees. I'd say this is fairly representative of their normal working-state."

The report comes after another revealed that the Chinese government may be looking to lift its 13-year ban on home games consoles. Maybe this will speed up the proposal.

Via: kotaku.com Via: shanghaiist.com

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Source: http://www.willamettelive.com/2013/arts-entertainment/the-art-of-documentary-photography-art-highlights-for-11013-12313/

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Saturday, January 26, 2013

Contrary to reports, the Irish haven't legalized drunk driving

Reports concerning an Irish county council's proposal to allow rural inhabitants to drive after drinking have been greatly exaggerated.

By Jason Walsh,?Correspondent / January 23, 2013

Reported around the globe as a license to drive drunk, an Irish council's motion to permit rural pub-goers to get behind the wheel not only lacks force of law, it's also a slightly odd solution to a serious issue.

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It's not often that a vote by five county councilors in rural west Ireland makes headline news, but Danny Healy-Rae managed it this week when he and four colleagues passed a motion to allow drinkers to drive home ? albeit at a severely restricted speed and only on barely-used backroads.

The political response? The same as that of the Irish public: bafflement and embarrassment.

Leo Varadkar, minister for transport, said he disagreed with the council's motion and stressed the affect of the story spreading across the globe. "It doesn't really send out a good message internationally about Ireland," he said.

One fact that has barely been reported in the scramble to play-up rural Irish alcoholic clich?s: It's not going to happen. As a county council motion, the proposal has no legal status.

Irish people are keenly aware of the country's drink-sodden image, with many feeling Mr. Healy-Rae's motion plays to outdated prejudices about the country.

The move may not seem so out of the blue as it first sounds, though. Not quite, anyway.

Healy-Rae proposed the motion as a response to isolation in rural areas, particularly among the elderly and would help to counter "depression and suicide." He said permits could be issued allowing holders to have "two or three drinks" and then still drive home.

"They're traveling on very minor roads, often on tractors, with very little traffic and it's not right they're being treated the same as the rest of the traveling public and they have never killed anyone," he said.?"The only outlet they have then is to take home a bottle of whiskey," he says, "and they're falling into depression, and suicide for some of them is the sad way out."

To be sure, pubs in country areas of Ireland are at the center of community life and are more than just drinking dens, which is something even the motion's critics acknowledge. And going to the pub and drinking nonalcoholic drinks is already an option, as is the option of hiring a bus.

Healy-Rae is a member of a colorful County Kerry political dynasty known for rural populism ? and occasional support for strange causes including, most recently, removing the number 13 from vehicle license plates.

He is also a pub owner ? as are three more of the total five councilors who supported the idea. Three voted against the idea, seven abstained, and 12 were absent from the meeting.

Despite widespread criticism, the motion has attracted some support. Independent Galway councilor Michael Fahy says he will raise the idea at the next council meeting.

The chances of the government agreeing to the idea? Less than the amount of alcohol in a glass of tap water. The country has worked hard in recent decades to reduce road deaths, both by upgrading the road network and by stricter enforcement of the rules of the road.

Ireland's road death rate hit an all-time low in 2012, with 161 lives lost, 25 fewer than the previous year. It is has the sixth lowest road death rate the in EU.

Source: http://rss.csmonitor.com/~r/csmonitor/globalnews/~3/ChkwObD-QGA/Contrary-to-reports-the-Irish-haven-t-legalized-drunk-driving

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Fidelity strategist: Market used to DC gridlock

BOSTON (AP) -- Has the stock market finally entered a comfort zone?

Consider that the Standard & Poor's 500 index on Friday closed above 1,500 points for the first time since December 2007. Fourth-quarter earnings are mostly coming in strong. Less than four weeks into the year, stocks already are up 5 percent.

Anxiety has eased so much that the Chicago Board of Options Exchange Volatility Index, also known as the VIX, has dropped to its lowest level in nearly six years. Referred to as the market's fear gauge, it reflects expected movement in the S&P 500 over the next 30 days, as measured by options prices.

What's more, investors are finally returning to the market. U.S. stock mutual funds attracted nearly $13 billion in net deposits during the first two weeks of the year. That's an about-face from 2012, when withdrawals exceeded deposits for 24 weeks in a row, ending in late December.

A key reason that investors are back is the Jan. 1 deal between Congress and the White House to avert the so-called "fiscal cliff." Thorny issues remain unresolved, including spending cuts and potential reforms to entitlement programs like Social Security and Medicare. But there's no longer an immediate threat of fiscal disaster.

When stocks are rallying as they are now, investors should exercise caution. The market is up more than 120 percent since early 2009, and the strongest returns may be behind us.

Yet Bruce Herring of Fidelity Investments is confident that the long-term outlook remains bright. As a chief investment officer with Boston-based Fidelity, Herring helps oversee more than $500 billion in stock assets.

Herring explained his belief that stocks offer strong growth potential because investors face far fewer economic and political uncertainties than they did a few years ago. Below are excerpts from an interview, edited for clarity:

Q: What's the key reason that you're optimistic?

A: We're starting to achieve a level of clarity we haven't had in a long time, and that's really powerful for stocks. For starters, there's less uncertainty in Washington. In President Obama's first term, there were many crises and several industries came under increasing scrutiny and regulation. With so much uncertainty, companies behaved conservatively. They stopped hiring, cut capital spending plans and they didn't raise dividends.

With the election behind, we know we'll continue to have Democrats and Republicans each controlling one chamber of Congress, and a president entering his second term. We'll still have partisanship. But we're starting to get clarity around policies on financial services, energy and other areas. And we've got clarity about tax policy. We haven't had that in years.

Q: What makes you optimistic about the economy?

A: We're seeing a recovery in the housing market, and that matters to everybody, from corporate CEOs to consumers. A rising housing market is a powerful backdrop to general economic activity and the stock market broadly. Confidence matters a ton. Stocks are rallying this year because the market is operating on a longer time horizon, now that there's more clarity.

Q: But unemployment remains high, and there are other troubling signs in the economy.

A: Yes, but it's better when you look at what drives the stock market, and that's corporate earnings. Stocks continue to be priced inexpensively relative to the earnings they generate and we're seeing decent earnings growth. And America's competitiveness is very strong. Natural gas is incredibly cheap, and we've got an efficient and strong labor force. We've had lots of productivity improvements in corporate America and modest wage growth.

Q: How will uncertainty about fiscal issues in Washington affect the markets in the next few months?

A: There's incredible partisanship, which is obviously dysfunctional. When we had the debt ceiling debate and resulting credit downgrade in the summer of 2011, stocks fell about 20 percent in short order. But there was no comparable decline leading up to the recent fiscal cliff deal. Washington has found a new way to negotiate and the markets seem to be getting used to it.

In coming months, I suspect we'll have more last-minute compromises that won't make Republicans or Democrats happy, but will advance the ball a little bit. It doesn't matter much for corporate America, and for the market and average consumers. The economy and the strength of corporate profitability is what really matters.

Q: What do the stock market fundamentals tell you now?

A: Long-term, the case for stocks is great. We've got a low starting point for the market, after we've gone through a period of about 13 years where the market has generated no real returns based on stock price changes. Stocks have generated only a modest return if you factor in dividends. About a dozen years ago, stocks were trading at an average of about 26 times their expected earnings. Now, they're trading at about half that level, or 13 times expected earnings, so stocks are relatively inexpensive. Earnings have roughly doubled over the last decade, but the market has basically been flat.

Q: How do you explain the huge sums withdrawn from stock funds the past few years, and the huge amounts that have gone into bonds?

A: It's not surprising after what we've been through over the past dozen years. We've had the Sept. 11, 2001 terrorist attacks, wars in Iraq and Afghanistan, oil hitting $100 a barrel, a housing market meltdown and a financial crisis. There's been a lot of volatility in the stock market and people have been burned. The problem is that people tend to sell at the wrong time and lock in their losses, which makes it even worse.

Q: Can those investors get it right in the coming years?

A: Maybe not. My biggest worry is that 2008 was such a damaging experience to the psyche of America, especially for investors who were potentially less sophisticated and for those close to retirement. Their behavior has been influenced for a long time and possibly permanently. So I'm a little worried that as the market keeps rallying and investors perceive the market as less risky, the people who got out four to five years ago will think it's OK to get back in. I hope that people will come back to stocks, so that they're a consistent part of their portfolios over time. They're an asset class that's shockingly out of favor, despite good returns.

___

Questions? E-mail investorinsight(at)ap.org

Source: http://news.yahoo.com/fidelity-strategist-market-used-dc-222702474.html

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U.N. urges Syria's neighbors to keep open borders to exodus

GENEVA (Reuters) - The United Nations on Friday urged Syria's neighbors to keep open their borders to civilians fleeing the intensifying conflict and said that the refugee exodus into Jordan was "absolutely dramatic".

More than 30,000 Syrians have arrived in Jordan's main Zaatri camp this year, including 4,400 on Thursday and another 2,000 overnight, it said. Most were fleeing fighting in the southern area of Deraa, food and fuel shortages and high prices.

Turkey has said that camps are filling up as soon as they are built and officials in Jordan said this week it would keep its borders open but wanted other countries to help it boost its ability to cope with the influx.

"It is just absolutely dramatic the inflow of people that continues into Jordan," Melissa Fleming, chief spokeswoman of the U.N. High Commissioner for Refugees (UNHCR), told a news briefing in Geneva.

Jordan now hosts more than 206,000 Syrians who have registered as refugees or await processing, while the government says that more than 300,000 Syrians are actually in the country.

A further 30,000 Syrians could be preparing to head to Jordan, according to the UNHCR's latest assessment.

Across the region, 678,540 Syrian refugees had registered or were being processed as of Tuesday, according to UNHCR figures for Jordan, Turkey, Lebanon, Iraq and North Africa.

"It is fast approaching 700,000," spokeswoman Sybella Wilkes told Reuters. "It is a challenge on every border the number of people that are arriving and crossing borders every day."

Fleming said the UNHCR commended the Jordanian, Lebanese and Turkish governments for keeping their borders open and urged them to continue to do so.

Refugees report fighting in Deraa and its suburbs but the UNHCR was not in a position to assess military activities, she said. Water and electricity are only available for intermittent periods in parts of southern Syria.

Some 25,000 to 40,000 Syrians are reported to be massed in northern Syria along Turkey's border, awaiting entry into the country which has 15 refugee camps and is building a further five, Fleming said.

"They are building camps as fast as they can and they are letting people in as soon as the camps are ready," she said.

What began as a mostly peaceful movement against President Bashar al-Assad has killed more than 60,000 people in 22 months, devastated the economy and left 2.5 million people inside the country hungry, according to the U.N.

Ted Chaiban, UNICEF director of emergency programs who was in Syria last week, said food, basic medicines and drinkable water were getting harder to find, while families were living 20 to a room with minimal shelter and clothing in cold weather.

(Reporting by Stephanie Nebehay; Editing by Jon Boyle)

Source: http://news.yahoo.com/u-n-urges-syrias-neighbors-keep-open-borders-131751638.html

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Friday, January 25, 2013

Pentagon cinching in its belt ahead of budget cuts

WASHINGTON (Reuters) - The Pentagon has begun laying off many of its 46,000 temporary and contract workers and delaying maintenance on aircraft and ships to slow spending due to fears it may be hit by new budget cuts, Deputy Defense Secretary Ashton Carter said on Friday.

The Pentagon also plans to formally notify Congress in the next few weeks that if further budget cuts take place on March 1, it will furlough most of its 800,000 full-time civilian employees, probably by asking them to take a day off per week for the last 22 weeks of the fiscal year, Carter said.

"Obviously this is a terrible thing to have to do to our employees and to the mission," Carter said. "But it's necessary because it'll save $5 billion and we have to find that money."

The cost-cutting steps come as the Pentagon tries to deal with budget uncertainty caused by the threat of $45 billion in across-the-board spending reductions on March 1 and Congress's failure to appropriate defense funding for the 2013 fiscal year.

The Pentagon currently is absorbing $487 billion in cuts to projected defense spending over 10 years that were agreed in the Budget Control Act of 2011. That law also required the additional across-the-board cuts by January 1, 2013, unless Congress agreed to an alternative.

Lawmakers failed to reach a new deal but did agree to postpone the across-the-board cuts until March 1 to give themselves more time. But March 1 is five months into the fiscal year, giving the Pentagon less time to absorb any cuts.

Defense officials had long resisted taking action in response to the threat of additional reductions, saying they were put in place to try to force Congress to reach an alternative.

But Carter said the congressional debate on U.S. financial issues in late December had been sobering, with little discussion of how cuts would affect the Pentagon or its mission. Postponing the decision for another two months reduced the time the department would have to respond.

"When we were marching up to January 1 we had more runway, more time to absorb cuts if we had to absorb cuts," Carter said. "Now we're running out of time and so for those two reasons, our risk calculus has to change ... and we need to begin acting."

Carter asked the military services two weeks ago to take steps to reduce their rate of spending. He said he asked them for detailed plans by February 1 on what they are doing to reduce short-term spending before the $45 billion in new cuts are due to go into effect on March 1.

He also asked for detailed long-term planning by February 8 on how the services will implement the $45 billion in across-the-board cuts if they go into effect.

BUDGET MESS

Congressional failure to allocate funding for defense for the 2013 fiscal year has complicated the Pentagon's budget mess. The department is currently operating on a continuing resolution that maintains funding at 2012 levels until March 27.

"The problem is that the money is in the wrong pots," Carter said. He said the Pentagon had planned to spend considerably more for operations and maintenance in 2013 than it did in 2012.

"We don't have enough money to operate the forces in the way we thought we were going to," Carter said. "That's the problem. And that's a more than $10 billion problem. And we're running out of time to eat that $10 billion and that's the reason that we need to act now."

To slow the rate of spending, the department has put a freeze on civilian hiring, he said. Usually the department hires 1,000 to 2,000 civilians a week, more than 44 percent of them military veterans and 86 percent of them living and working across the country, not in Washington.

The department's 46,000 temporary and contract employees are "all now subject to release," Carter said, meaning they will either be let go now or will not have their contracts extended. The only exception would be if they are performing jobs critical to the war or the department's basic mission.

The department also is cutting back on base and equipment maintenance, which costs about $15 billion per year. He said the Navy would cancel maintenance on 30 ships that had been planned for the third and fourth quarters this year.

"They're not going to sign those contracts with the shipyards that do that work," Carter said.

Carter said the Pentagon would have to do "more draconian things" if Congress allows the $45 billion in cuts to go into effect, likely leading to "a pervasive crisis in readiness."

He said the Army projected that if the cuts occur, two-thirds of its active brigades and all of its reserve brigades would be operating at reduced readiness. Funds for training would primarily be used to prepare troops deploying to Afghanistan, while others would largely do without, he said.

Most Air Force flying units would be at reduced readiness by the end of the year, he said. The Navy would have to cut back steaming days by 30 percent to 35 percent, affecting its presence in the Gulf and Asia-Pacific region. He said the cuts might affect the U.S. ability to keep two carriers in the Gulf.

(Reporting by David Alexander; Editing by Vicki Allen and Doina Chiacu)

Source: http://news.yahoo.com/pentagon-cutting-jobs-maintenance-due-budget-fears-official-170708494--business.html

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Cells 'flock' to heal wounds

Friday, January 25, 2013

Like flocks of birds, cells coordinate their motions as they race to cover and ultimately heal wounds to the skin. How that happens is a little less of a mystery today.

Researchers once thought only the cells at the edge of a growing patch of wounded skin were actively moving while dividing cells passively filled in the middle. But that's only part of the picture. Rice University physicist Herbert Levine and his colleagues have discovered that the process works much more efficiently if highly activated cells in every part of the patch exert force as they pull their neighbors along.

There's a need to understand how cells cooperate to protect the site of a wound in the hours and days after injury, said Levine, who has introduced the first iteration of a computer model to analyze the two-dimensional physics of epithelial sheets. He hopes it will give new insight into a process with long-term implications not only for healing but also for understanding cancer, a prime motivator in his research since joining Rice under a grant from the Cancer Research and Prevention Institute of Texas.

A paper on the research by Levine, based at Rice University's BioScience Research Collaborative, and colleagues at the University of California at San Diego and in Germany and France appears this week in the Proceedings of the National Academy of Science.

Levine and his colleagues create computer models of processes seen by experimentalists to flesh out the rules that govern biological systems. "Here, we're combining experimental observations from single cells with general notions from the physics literature to create an integrated way of thinking about this multicellular system," he said.

The new models were prompted by a recent Harvard study showing "that even in the middle of a sheet, cells were dynamically creating heads and tails and were actively moving rather than being passively carried along," Levine said. "This data convinced us that we needed a different way to start to think about the problem."

The body marshals an astounding array of forces to heal wounds, Levine said. Many have to do with cell biology, the internal and external signals that tell a cell when to move, when to stop, when to split and when to die. His team's intent was to focus first on the cell's physical interactions with its neighbors and study what happened if all those complicating factors are eliminated from the simulations.

"We try to unravel what is physics and what is biology," Levine said. "We want to know which parts of the phenomenon don't require sophisticated signaling networks."

In the physics approach to cell motility, he said, "the first thing to do is see how far we can get if we assume that all the cells are following the same rules. Then the only thing that's creating the dynamics of the system is that they're interacting with each other. This is the type of problem that physicists have studied before, usually in nonbiological contexts."

In the Harvard experiment, he said, "They had taken a millimeter-sized tissue that was spreading and showed it wasn't just cells on the end that were pulling on the tissue while the others were spectators." But that work didn't explain how cells in the center of the tissue knew the direction of the edge.

Levine's team looked to the skies for inspiration. "Birds look around and decide which way all their neighbors are flying," Levine said. "The idea that they would move as independent birds but also coordinate is where the idea of flocking came from. This way of thinking hadn't been applied to epithelial tissue motility in wound healing."

What cells "see" are their sticky neighbors, which pull and tug them as they move on lamellipodia, thin sheets that serve as "feet" powered by actin filaments that act something like the treads on a tank. The overlapping lamellipodia of adjacent cells influence each other. "The cells have to figure out which way to go based on competing tendencies: their own tendency to push on the ground and propel themselves forward, and the tendency of their neighbors to try to pull them in various directions," Levine said. "Our basic notion is that as time goes on, these tendencies become correlated as the cell 'tries' to accommodate its conflicting inputs."

The Harvard experimentalists saw that loosely packed cells in the middle of a growing colony tend to swirl in a disorganized manner, and the simulations confirmed this. These swirls are analogous to what is seen in other examples of flocking. But when a wound is introduced, the swirls disappear and cells begin to match direction and velocity and pull toward a common goal. The ones on the edge immediately know which way to go, and everyone else learns from their example. Surprisingly, Levine said, "stickier" cells tend to push forward unevenly, with finger-like protrusions at the leading edge, much like what experimentalists often see.

The simulation model has a long way to go, Levine said. "It's rough around the edges. Biologists who read this will immediately say, 'You've left out all sorts of interesting things we know are happening.'

"Yes, there will be experiments for which this approach will not be sufficient," he said. "It will teach us that in those cases, biology has to exert a more specific role in creating the structures and the motion."

Levine hopes to match the models to current work by experimentalists on motility in cells related to the metastatic spread of breast cancer. "We're a long way from saying anything about this problem," he said. "But that's my overall agenda -- to push my research to where it can make contact with the cancer community."

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Rice University: http://media.rice.edu

Thanks to Rice University for this article.

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